WHY IT MATTERS
digital illustration of DNA strands
digital illustration of DNA strands
Darwin's Cats: typography
male scientist conducting research in lab using vial samples

ADVANCING FELINE HEALTH THROUGH COMMUNITY SCIENCE

By Claire Hendershot
Photos provided by Darwin’s Ark

Cats are cherished companions in more than 40 million U.S. households,1 yet scientists understand surprisingly little about feline biology, behavior and genetics. This lack of foundational knowledge limits the information and tools veterinarians have to diagnose and treat their feline patients.

Fortunately, Darwin’s Ark, a community science nonprofit, is working to change that with its ambitious research initiative, Darwin’s Cats. In partnership with scientists at UMass Chan Medical School and the Broad Institute,2 Darwin’s Cats is building the most comprehensive feline dataset ever assembled to accelerate research on cat genetics and health.

Breaking Barriers in Feline Research
Despite nearly 85% of cat owners considering their cats part of their family,3 they are chronically underrepresented in pet research and clinical studies.4 Most existing cat studies focus only on small sample sizes or specific breeds, leaving the vast majority of the pet-cat population out of the research picture.

This deficit in scientific research is particularly obstructive to understanding how genetics influences cat behavior and health. Without robust phenotypic and genotypic data, it’s difficult to identify risk factors for common feline diseases, much less develop targeted diagnostics or treatments.

These challenges are then exacerbated by the relative infrequency with which cat owners taker their pets to the veterinarian, with only 40% of cats visiting the vet annually, compared to 82% of pet dogs5—another key way that scientists gather information about feline health.

“To better understand and treat cats, we need information from both genetic sequences and clinical observations,” states Michelle White, DVM, PhD, a veterinary scientist at the Broad Institute. “But because cats are sequenced less often, and they’re seen less at the vet, they’re harder to study.”

small pink comb being ran through the top of a black and white cat's head
Catalyzing Discovery with Community Science
Darwin’s Cats sidesteps these limitations with a more accessible approach to feline research: community science, which is a collaborative research effort between professional scientists and members of the general public.

Darwin’s Cats puts owners at the forefront of research by inviting them to become community scientists. Participants share their unique insights through online surveys about their cats’ physical traits, health, behaviors and environment. Darwin’s Cats also invites cat owners to sequence their cat’s DNA using a novel fur-based sequencing method that is a first in pet science.6

tray collection of vial samples
web page screenshot of Darwin's Ark research surveys
digital illustration of DNA strands
A deeper understanding of the cat genome will help veterinary scientists investigate a wide range of feline health determinants, including the complex interplay between genes and environment on cat health.
This at-home approach not only broadens participation but ensures data accuracy by capturing cats’ behavioral profiles at home, where they’re most comfortable. Cat owners’ observations are combined with whole genome sequences to create a large-scale database that’s growing by the day.

“No one observes cats more than the people who live with them,” says Elinor Karlsson, Darwin’s Ark co-founder and chief scientist. “By collecting millions of those observations and combining them with thousands of whole genome sequences, Darwin’s Cats is creating a scientific resource that I believe has the potential to transform our genetic understanding of cats.”

Launched just last year, Darwin’s Cats is already the largest community-driven feline research project with more than 14,000 cats enrolled, over one million survey questions answered and nearly 1,000 cats participating in DNA sequencing. But the initiative has bigger ambitions, aiming to enroll 100,000 cats and sequence 5,000 genomes by the end of 2026.

Large-scale data collection opens the door to studying complex traits at a population level, from behavioral temperament and genetic predispositions to how cats respond to medications, certain diets and environmental stressors. Just as large-scale genomic studies have reshaped canine and human health research,7 Darwin’s Cats is building a resource that can do the same for feline health.

A Better Understanding of Cat Health
While its near-term focus is on large-scale data collection, Darwin’s Cats’ ultimate goal is to catalyze breakthroughs in cat research by deepening understanding of the genetic foundations of cat health and wellbeing. The initiative’s integration of large phenotypic and genotypic datasets will provide veterinary scientists with better information and more resources for diagnosing, treating and preventing disease in cats.

A deeper understanding of the cat genome will help veterinary scientists investigate a wide range of feline health determinants, including the complex interplay between genes and environment on cat health. If survey and sequencing data suggest that a trait is mainly driven by environmental factors, intervention might involve modifying a cat’s surroundings. If researchers identify an association between a trait and a genetic marker, there may be potential for targeted drug development or gene-based diagnostic screening.

Darwin’s Cats operates under an open science framework, which means that the initiative’s anonymized data will be made available to other researchers to advance their own work without needing to independently fund or recruit for duplicative studies. This collaborative approach ensures that discoveries don’t stay siloed, but rather contribute to a shared, evolving understanding of feline science.

In the long-run, Darwin’s Ark hopes its open science commitment will accelerate the development of feline-specific therapies rather than relying on adaptations from human or canine medicine.
Darwin's Ark logo
Getting Involved with Darwin’s Cats
Veterinarians are uniquely poised to both benefit from and contribute to this groundbreaking scientific resource. With extensive clinical experience and connections to pet owners, veterinarians can play an important role in ensuring Darwin’s Cats improves health outcomes for cats everywhere.
Here’s how to contribute:
  • Join Darwin’s Cats as a community scientist. If you have a cat of your own, your clinically informed insights on their health and behavior are especially useful data points.
  • Encourage your clients to participate. Many cat lovers are eager to contribute to research that may help their cat—and all cats—live healthier, happier lives.
  • Tell us what you’d like to learn from this research. Darwin’s Ark invites veterinary professionals to share what survey data and research topics would be most helpful in providing cat care. Input from veterinary professionals is key in designing future surveys and setting research priorities.

To learn more or join the journey of discovery, visit www.darwinsark.org. Together, cat lovers, researchers and veterinarians can help cats live happier, healthier lives.

References:
  1. U.S. pet ownership statistics. (2024, December). American Veterinary Medical Association. https://www.avma.org/resources-tools/reports-statistics/us-pet-ownership-statistics
  2. Darwin’s Ark Teams Up with Hill’s Pet Nutrition and Leading Research Institutions to Explore Cats’ Genetic Code. (2025, April 24). Reuters. https://www.reuters.com/press-releases/darwin-s-ark-teams-up-with-hill-s-pet-nutrition-and-leading-research-institutions-to-explore-cats-genetic-code-2025-04-24/
  3. Pet population continues to increase while pet spending declines. (2024, October 10). American Veterinary Medical Association. https://www.avma.org/news/pet-population-continues-increase-while-pet-spending-declines
  4. Anthes E. Why are cats such a medical black box? (2025, March 11). The New York Times. https://www.nytimes.com/2025/03/11/science/cats-veterinarians-health.html
  5. 2025 Hill’s Pet Nutrition World of the Cat Report. (2025, April 2). Hill’s Pet Nutrition. https://na.hillsvna.com/en_US/resources-2/view/244
  6. Darwin’s Cats Invites Cat Lovers to Help Decode Feline DNA with a New Breakthrough in Genetics Research. (2025, March 19). Reuters. https://www.reuters.com/press-releases/darwin-s-cats-invites-cat-lovers-to-help-decode-feline-dna-with-a-new-breakthrough-in-genetics-research-2025-03-19/
  7. Bautista-Alejandre A. New global cat report released as feline medicine continues to lag behind its canine counterpart. (2025, April 16). DVM 360. https://www.dvm360.com/view/new-global-cat-report-released-as-feline-medicine-continues-to-lag-behind-its-canine-counterpart
Claire Hendershot headshot
Claire Hendershot is a freelance science writer who frequently writes for Darwin’s Ark, a nonprofit that catalyzes groundbreaking genetics research by engaging pets and their people in scientific discovery. By uniting pet lovers with leading scientists and cutting-edge genomic technology, Darwin’s Ark explores the genetic foundations of health and behavior, working to advance scientific discoveries that improve health and well-being for both pets and people.